Laboratory for Nanomedicine
S i r i a n n i R e s e a r c h G r o u p




Current Grant Support
Exploiting sex-dependent brain injury responses for nanoparticle therapeutics (R01)
Project duration: 01/01/2021 - 12/31/2026
Sponsor: The National Institutes of Health, NINDS
MPI: Stabenfeldt/Sirianni
Intrathecal delivery of radiation sensitizing nanoparticles (R01)
Project duration: 07/01/2019 – 06/31/2024
Sponsor: The National Institutes of Health, NICHD
PI: Sirianni
Targeting leptomeningeal metastasis in medulloblastoma (R01)
Project duration: 05/01/2019 – 04/30/2024
Sponsor: National Institutes of Health, NINDS
PI: Sirianni
Inhibiting metastasis and preventing recurrence in MYC-amplified medulloblastoma
Project duration: 05/01/2020 - 04/31/2023
Sponsor: The Matthew Larson Foundation
Role: co-I (PI, Yanxin Pei)
Past Grant Support
Biomimetic microenvironments to model leptomeningeal metastasis in pediatric neuro-oncology
Project duration: 03/01/2019 – 02/28/2020
Sponsor: The Morgan Adams Foundation
PI: Sirianni
Nanotherapeutics to alleviate neuroinflammation after TBI (R21)
Project duration: 7/1/2018 – 6/30/2020 (through 2021 under NCE)
Sponsor: National Institutes of Health, NINDS
MPI: Stabenfeldt/Sirianni
Faculty Science and Technology Acquisition and Retention (STARs) Award
Project duration: 7/1/2018-6/31/2020
Sponsor: The University of Texas Health Science Center at Houston
PI: Sirianni
Intra-CSF delivery of targeted nanoparticles to treat leptomeningeal metastasis
Project duration: 7/18/2018-7/17/2019
Sponsor: Ian’s Friends Foundation
PI: Sirianni
Detecting and treating traumatic brain injury pathology progression from the inside-out – Supplement for AD/ADRD research (DP2)
Project duration: 9/11/2018 – 6/30/2019
Sponsor: National Institutes of Health, NICHD/NIA
PI: Stabenfeldt (co-I: Sirianni)
Central nervous system targeted drug delivery
Project duration: 7/1/2017-6/30/2019
Sponsor: 2016 Women’s Board Project (Barrow Neurological Foundation)
PI: Sirianni
Pathogen-Inspired Nanoparticle Drug Delivery to Motor Neurons
Project duration: 8/5/2014 – 8/4/2016
Sponsor: Department of Defense, CDMRP
PI: Sirianni
Nanotechnology to treat glioblastoma
Project duration: 7/1/2014 – 6/7/2018
Sponsor: The Rick Oehme Foundation
PI: Sirianni
Expanding Therapeutic Options for Glioblastoma
Subaward: Delivery of drugs across the blood brain barrier
Project duration: 11/1/2013 – 12/31/2015
Sponsor: The Ben and Catherine Ivy Foundation
PI: Michael Berens (subaward PI: Sirianni)
Support for Trainees
Modulating retinoid signaling as a therapeutic approach for ALS
Project duration: 8/1/2015-7/31/2017
Sponsor: The ALS Association
Recipient: David Medina, Ph.D.
Development of targeted delivery of estrogen to examine its effect on cognitive function (NSF GRF)
Project duration: 6/1/2014-5/31/2017
Sponsor: National Science Foundation
Recipient: Alesia Prakapenka