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Original Research Articles

2021 -

    1.  [PDF]. Chaudhuri S, Fowler MJ, Baker C, Stopka SA, Regan MS, Sablatura LK, Broughton CW, Knight BE, Stabenfeldt SE,               Agar NYR, Sirianni RW*. Beta-cyclodextrin-poly(beta-amino ester) nanoparticles are a generalizable strategy for high                       loading and sustained release of HDAC inhibitors in the CNS in press, ACS Applied Materials and Interfaces. IF = 8.76


    1.  [PDF]. Prakapenka AV, Peña VL, Strouse I, Northup-Smith S, Schrier A, Ahmed K, Bimonte-Nelson HA*, and Sirianni                    RW*. Intranasal 17β-estradiol modulates spatial learning and memory in a rat model of surgical menopause Pharmaceutics: in               press. IF = 4.9   

    2. [PDF]. Prakapenka AV, Quihuis AM, Carson CG, Patel S, Bimonte-Nelson HA, Sirianni RW*. Poly(lactic-co-glycolic acid)             nanoparticle encapsulated 17β-estradiol improves spatial memory and increases uterine stimulation in middle-aged                               ovariectomized rats Frontiers in Behavioral Neuroscience: in press. IF = 3.1

    3. [PDF]. Medina DX, Chung EP, Teague C, Bowser RP, Sirianni RW*. Intravenously administered, retinoid activating                               nanoparticles increase lifespan and reduce neurodegeneration in the SOD1G93A mouse model of ALS Frontiers in                               Bioengineering and Biotechnology 8:224 (2020) IF = 5.1

    4. [PDF]. Sandberg DI*, Kharas N, Yu B, Janssen CF, Trimble A, Ballester LY, Patel R, Mohammad AS, Elmquist WF, Sirianni               RW. (2020) High Dose MTX110 (Soluble Panobinostat) Safely Administered into the Fourth Ventricle in a Non-human                     Primate Model Journal of Neurosurgery: Pediatrics 1-9 (epub ahead of print) IF = 2.1

    5. [PDF]. Chung EP, Cotter JD, Prakapenka AV, Cook RL, DiPerna DM, Sirianni RW*. Targeting Small Molecule Delivery to                the Brain and Spinal Cord via Intranasal Administration of Rabies Virus Glycoprotein (RVG29)-Modified PLGA                                   Nanoparticles. Pharmaceutics. 12(2):93

​2019 -

  1. [PDF]. Householder KT, Wechsler-Reya RJ, Sandberg DI, Sirianni RW*. Evaluating the fate of nanoparticles of nanoparticles within the central nervous system following intrathecal administration. Scientific Reports. 12587(2019). (Published online Aug 29th, PMID pending)

  2. [PDF]. Medina DX, Chung EP, Teague C, Bowser RP, Sirianni RW*. (2019) Adapalene-loaded, lipid and polyester blended nanoparticles for activation of retinoid signaling in the central nervous system. Journal of Drug Delivery Science and Technology. 52:927-933

  3. [PDF]. Sandberg DI*, Yu B, Patel R, Hagan J, Miesner E, Sabin J, Smith S, Fletcher S, Shah MN, Sirianni RW, Taylor MD. (2019) Infusion of 5-Azacytidine (5-AZA) into the fourth ventricle or resection cavity in children with recurrent posterior fossa ependymoma: a pilot clinical trial. Journal of Neuro-Oncology. 141(2):449-457

2018 -

  1. [PDF]. Householder KT, DiPerna D, Sirianni RW*. (2018) pH driven precipitation of quisinostat onto PLA-PEG nanoparticles enables treatment of intracranial glioblastoma. Colloids and Surfaces B: Biointerfaces 166:37-44

  2. [PDF]. Moutal A, Villa L, Yeon S, Householder KT, Park KD, Sirianni RW, Khanna R*. (2018) CRMP2 phosphorylation drives glioblastoma cell proliferation. Molecular Neurobiology. 55(5):4403-4416

  3. [PDF]. Prakapenka AV, Hiroi R, Quihuis AM, Carson C, Patel S, Berns-Leone C, Fox C, Sirianni RW, Bimonte-Nelson HA*. (2018) Contrasting effects of individual versus combined estrogen and progestogen regimens as working memory load increases in middle-aged ovariectomized rats: one plus one does not equal two. Neurobiol Aging. 64:1-14

  4. [PDF]. Diperna DM, Prakapenka AV, Chung EP, Sirianni RW*. (2018) Non-enzymatic tissue homogenization for biodistribution analysis. Methods in Molecular Biology 1831:191-199

  5. [PDF]. REVIEW. Heffernan JM, Sirianni RW*. (2018) Modeling microenvironmental regulation of glioblastoma stem cells: a biomaterials perspective. Frontiers in Materials. 5(7)

2017 -

  1. [PDF]. Heffernan JM, McNamara JB, Borwege S, Vernon BL, Sanai N, Mehta S, Sirianni RW*. (2017) PNIPAAm-co-Jeffamine (PNJ) scaffolds as in vitro models for niche enrichment of glioblastoma stem-like cells. Biomaterials 143:149-158

  2. [PDF]. Medina DX, Householder KT, Ceton R, Kovalik T, Heffernan J, Shankar RV, Bowser RP, Wechsler-Reya RJ, Sirianni RW*. (2017) Optical barcoding of PLGA for multispectral analysis of nanoparticle fate in vivo. Journal of Controlled Release 10;253:171-182 PMID: 28263836

  3. [PDF]. REVIEW. Prakapenka AV, Bimonte-Nelson HA, Sirianni RW*. Engineering poly(lactic-co-glycolic acid) micro- and nano-carriers for controlled delivery of 17β-estradiol. Annals of Biomedical Engineering 45(7):1697-1709

2016 -

  1. [PDF]. Addington CP, Dharmawaj J, Heffernan JM, Sirianni RW, Stabenfeldt SE*. (2016) Hyaluronic acid-laminin hydrogels increase neural stem cell transplant retention and migratory response to SDF-1alpha. Matrix Biology 60-61:206-216 PMID: 27645115

  2. [PDF]. Kobes JE, Daryaei I, Howison CM, Bontrager JG, Sirianni RW, Meuillet EJ, Pagel MD*. (2016) Improved treatment of pancreatic cancer with drug delivery nanoparticles loaded with a novel AKT/PDK1 inhibitor. Pancreas 45(8):1158-66 PMID: 26918875

  3. [PDF]. Navaeis A, Truong D, Heffernan JM, Cutts J, Brafman D, Sirianni RW, Vernon BL, Nikkhah M*. (2016) PNIPAAm-based biohybrid injectable hydrogel for cardiac tissue engineering. Acta Biomaterialia 1(32):10-23 PMID: 26689467

  4. [PDF]. Dutta D, Salifu M, Sirianni RW*, Stabenfeldt SE*. (2016) Tailoring sub-micron PLGA release profiles via centrifugal fractionating. Journal of Biomaterials Research: Part A. 104(3): 688-696. PMID: 26517011

  5. [PDF]. Heffernan JM, Overstreet DJ, Srinivasan S, Le LD, Vernon BL*, Sirianni RW*. (2016) Temperature responsive hydrogels enable transient three-dimensional tumor cultures via rapid cell recovery. Journal of Biomaterials Research: Part A 104(1):17-25.  PMID: 26123863

2015 - 

  1. [PDF]. Cook RL, Householder KT, Chung EP, Prakapenka AV, DiPerna DM, Sirianni RW*. (2015) A critical evaluation of drug delivery from ligand modified nanoparticles: confounding small molecule distribution and efficacy in the central nervous system. Journal of Controlled Release 220(Pt A):89-97. PMID: 26471392

  2. [PDF]. Addington CP, Heffernan JM, Millar-Haskell CS, Sirianni RW, Stabenfeldt SE*. (2015) Enhancing neural stem cell response to SDF-1a gradients through hyaluronic acid-laminin hydrogels. Biomaterials 72:11-9. PMID: 26340314

  3. [PDF]. Householder KT, DiPerna D, Chung EP, Wohlleb G, Dhruv H, Berens M, Sirianni RW*. (2015) Intravenous delivery of camptothecin-loaded PLGA nanoparticles for the treatment of intracranial glioma. International Journal of Pharmaceutics. 479(2):374-380. PMID: 25562639

2014 - 

  1. [PDF]. Heffernan JM, Overstreet DJ, Le LD, Vernon BL, Sirianni RW*. (2014) Bioengineered hydrogels for 3D analysis of glioblastoma invasion and proliferation. Annals of Biomedical Engineering 43(8):1965-77. PMID: 25515315

  2. [PDF]. Sirianni RW, Zheng MQ, Patel TR, Schafbauer T, Zhou JB, Saltzman WM, Carson RE, Huang YY*. (2014) Radiolabeling of poly(lactic-co-glycolic acid)  (PLGA) nanoparticles with biotinylated F-18 prosthetic groups and imaging of their delivery to the brain with positron emission tomography. Bioconjugate Chemistry. 25(12):2157-65. PMID: 25322194

  3. [PDF]. REVIEW. McCall RL, Cacaccio J, Wrabel E, Schwartz ME, Coleman TP, Sirianni RW*. (2014) Pathogen-inspired drug delivery to the central nervous system. Tissue Barriers. 2:4, e944449-14

2013 - 

  1. [PDF]. McCall RL, Sirianni RW*. (2013) PLGA nanoparticles formed by single- or double-emulsion with vitamin E-TPGS. Journal of Visualized Experiments. (82):51015. PMID: 24429733

  2. [PDF]. Zhou JB, Patel TR, Sirianni RW, Strohbehn G, Zheng MQ, Duong N, Schafbauer T, Huttner AJ, Huang Y, Carson RE, Zhang Y, Sullivan DJ, Piepmeier J, Saltzman WM*. (2013) Highly-penetrative, drug-loaded nanocarriers improve treatment of glioblastoma. Proceedings of the National Academy of Sciences. 110(29): 11751-6. PMID: 23818631

  3. [PDF]. Sirianni RW, Zheng MQ, Saltzman WM, Huang Y, Carson RE*. (2013) Direct, quantitative, and noninvasive imaging of the transport of active agents through intact brain with positron emission tomography. Molecular Imaging and Biology. 15(5):596-605. PMID: 23624949

Pre 2013 -

  1. [PDF]. Sirianni RW, Olausson P, Chiu A, Taylor JR, Saltzman WM*. (2010) The behavioral and biochemical effects of BDNF containing polymers implanted in the hippocampus of rats. Brain Research. 1321(C): 40-50. PMID: 20096671

  2. [PDF]. Sirianni RW, Jang EH, Miller KM, Saltzman WM*. (2009) Parameter estimation methodology in a model of hydrophobic drug release from a polymer coating. Journal of Controlled Release. 142(3): 474-482. PMID: 19958804

  3. [PDF]. Sirianni RW, Kremer J, Guler I, Chen YL, Keeley F, Saltzman WM*. (2008) The effect of extracellular matrix elements on the transport of paclitaxel through an arterial wall tissue mimic. Biomacromolecules. 9(10): 2792-2798. PMID: 18785771

  4. [PDF]. Solis FJ, Weiss-Malik RA, Vernon BL*. (2005) Local monomer activation model for phase behavior and calorimetric properties of LCST gel-forming polymers. Macromolecules. 38(10): 4456-4464. DOI: 10.1021/ma047895a

  5. [PDF]. Weiss-Malik RA, Solis FP, Vernon BL*. (2004) Independent control of lower critical solution temperature and swelling behavior with pH for poly (N-isopropylacrylamide-co-maleic acid). Journal of Applied Polymer Science. 94(5): 2110-2116. DOI: 10.1002/app.21000


  1. [PDF, introduction]. Co-editor (Sirianni/Behkam), "Targeted Drug Delivery". Methods in Molecular Biology (Springer/Humana Press) July 2018

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